??Triptolide 98% (CAS: 38748-32-2)

Plant Source: Tripterygium wilfordii Hook. f. (Thunder God Vine)
Molecular Formula: C??H??O? | Molecular Weight: 360.4 g/mol
Purity: ≥98% (HPLC-validated)
Appearance: White crystalline powder

?? Chemical & Physical Properties

?? Product Specifications

• CAS No.: 38748-32-2

• Synonyms: PG490, Tripdiolide, Triptolide

• Purity: ≥98% (HPLC, UV detection at 215-218 nm) 

• Packaging: 5 mg, 20 mg, 50 mg, 100 mg, 500 mg, 1 g (customizable) 

• Stability: Stable under recommended storage; avoid repeated freeze-thaw cycles 

  • 

     
  • 

     
  • 

     
  • 

     

   

?? Biological Activities & Mechanisms

?? In Vitro & In Vivo Efficacy

1. Anti-Cancer Activity:

   • Induces apoptosis in tumor cells by inhibiting c-IAP2/XIAP and enhancing TNF-α-induced cell death.

   • Targets HSF1-HSP90 complex, suppressing cancer cell proliferation (IC??: 47-73 nM).

   • Inhibits neuroblastoma colony formation and tumorigenicity in xenograft models.

2. Anti-Inflammatory & Immunosuppressive Effects:

   • Blocks NF-κB activation and TGF-β1/Smad signaling, reducing airway smooth muscle proliferation in asthma models.

   • Synergizes with cyclosporine A to suppress graft-versus-host disease (GVHD) .

3. Antiviral Action:

   • Downregulates Epstein-Barr virus (EBV) LMP1 protein, inhibiting B-lymphocyte proliferation.

4. Osteolysis Inhibition:

   • Suppresses RANKL-induced osteoclast formation and titanium particle-induced bone resorption in murine models.

?? Clinical & Research Applications

• Oncology: Potential therapeutic agent for neuroblastoma, leukemia, and solid tumors.

• Autoimmune Diseases: Validated for rheumatoid arthritis and asthma via TGF-β/Smad pathway inhibition.

• Organ Transplantation: Enhances allogeneic bone marrow transplant survival.

?? Experimental Protocols

1. Cell-Based Assays:

   • Use in DMSO at working concentrations (e.g., 10–100 nM for apoptosis studies).

   • Centrifuge vials before use to prevent compound adhesion.

2. Animal Studies:

   • Dose-dependent suppression of tumor growth (e.g., 0.1–0.3 mg/kg in mice).

?? Safety & Handling

• Toxicity: High acute toxicity (LD?? in mice: 0.8–0.9 mg/kg, intraperitoneal).

• Precautions:

  • Use personal protective equipment (gloves, N95 mask, eyeshields).

  • Avoid contact with strong acids/bases 7.

• Regulatory: For research use only. Not for human or veterinary drug applications.

?? Ordering & Support

• Quality Assurance: Batch-specific HPLC/NMR reports available.

• Customization: Bulk quantities (>1 g) and formulation support upon request.

• Shipping: Dry ice packaging for international delivery.