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High-Purity 20(R)-Ginsenoside Rg3 (CAS 38243-03-7) | Inhibits Tumor Metastasis | mg to kg Scale
20(R)-Ginsenoside Rg3 (CAS:38243-03-7) is a stereospecific ginsenoside derived from Panax ginseng, renowned for its dual anticancer and adaptogenic properties. With molecular formula C42H72O13 and HPLC-verified purity ≥98%, it serves as a critical reference standard in pharmaceutical research and herbal quality control.
Product Name :
20(R)-Ginsenoside Rg3CAS No. :
38243-03-7Appearance :
Brown to White PowderSpecification :
10%-98%CAS No.: 38243-03-7
Molecular Formula: C??H??O??
Molecular Weight: 785.01 g/mol
Source: Roots of Panax ginseng (Steam-processed red ginseng)
Appearance: White crystalline powder
Core Value: Anticancer & Immunomodulatory Agent with dual action against tumor proliferation and metastasis.
?? Key Differentiation: High selectivity for cancer cells (vs. normal cells) and water solubility enabling flexible formulations.
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-validated) |
| Melting Point | 315–318°C |
| Solubility | Soluble in water, methanol, ethanol; insoluble in petroleum ether/chloroform |
| Storage | 2–8°C (short-term); –20°C in desiccated, argon-protected containers (long-term) |
| Shelf Life | 24 months under cryo-storage |
| Identification | HPLC-UV, NMR, HRMS |
Tumor Suppression: Inhibits cancer proliferation by inducing apoptosis via p53/Bax pathways and blocking angiogenesis.
Metastasis Prevention: Acts as an MMP inhibitor to reduce tumor migration and invasion.
Chemotherapy Synergy: Enhances efficacy of cisplatin/paclitaxel while reducing toxicity.
NK Cell Activation: Boosts innate immunity to target residual cancer cells.
Adaptive Immune Support: Modulates T-cell responses for sustained antitumor effects.
Neuroprotection: Improves cognitive function and reduces neural oxidative stress.
Metabolic Adaptation: Enhances insulin sensitivity via AMPK pathway modulation.
| Sector | Use Cases |
|---|---|
| ?? Pharmaceuticals | Adjuvant cancer therapy; chemo-sensitizing formulations . |
| ?? Cosmeceuticals | Anti-aging serums (DNA repair), radioprotective creams . |
| ?? Research | Reference standard for oncology/immunology studies. |
| Quantity | Packaging | Lead Time |
|---|---|---|
| 20mg–100mg | Amber glass vials + desiccant | 3–5 days |
| 100mg–1kg | Vacuum-sealed foil bags | 5–8 days |
| >1kg | GMP cryo-containers | 15–30 days |
| Notes: |
Custom Blends: 1%–98% purity options (OEM supported).
Global Delivery: Door-to-door (FedEx/DHL); port-to-port for bulk.
Purity Validation: HPLC ≥98% with batch-specific CoA.
Safety Compliance: Heavy metals <10 ppm (USP/EP), NON-GMO, ISO 9001.
Regulatory Files: Full DMF and stability data (24 months) available.
Q1: Is (20R)-Rg3 cytotoxic to healthy cells?
→ No. Selectivity index: IC?? tumor cells <50 μM vs. normal cells >200 μM.
Q2: Stability in functional foods?
→ 24-month stability in gummies/beverages (pH 3–8, 25°C).
Q3: MOQ for nanonized formulations?
→ 100mg for R&D; 1kg+ for production (OEM support included).
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